Enhancements    

Christina Sobin

 
368
Health Sciences and School of Nursing Building
El Paso Texas, 79968
Homecasobin@utep.edu
Phone Logo(915) 747-8309
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CENTERS AND COMMUNITIES

Christina Sobin
Professor, Public Health Sciences - Interdisciplinary Health Sciences
Director, Master of Public Health Program, Department of Public Health Sciences

Dr. Sobin and her research team conduct interdisciplinary and translational research to examine brain and behavior outcomes of developmental exposure to lead, and novel solutions for mitigation in lower-income neighborhoods. Their outcome research focused on cognitive concomitants and sequelae of genetic variants that influence brain mechanisms vulnerable to the effects of developmental lead exposure. Child studies provided new evidence that the hPEPT2*2 genetic variant increased blood lead burden and predicted a specific pattern of deficits in exposed children. Results from Dr. Sobin's child studies guided the development of novel animal models and in these models, Dr. Sobin duplicated the low exposure levels of child participants, quantified loss of microglia in dentate gyrus, and characterized associated behavioral effects. These studies importantly served to substantiate the significant and lasting effects of early lead exposure at lowest levels of exposure and in an attempt to finally "fix" the problem of lead exposure in American children, the laboratory transitioned to the development of a novel child-guided approach for identifying groups of children in high-risk neighborhoods with current lead exposure, identifying the lead hazard sources in the homes, educating families regarding low-cost and safe mitigation and prevention, and are conducting follow up studies to examine whether these methods lower lead contamination in the homes (in household dust) and in the children. The mitigation approach is manualized and was designed to be readily adapted by cities across the U.S.

KEYWORDS

  1. Translational
  2. Interdisciplinary
  3. Child Lead Exposure
  4. Animal Models
  5. Dentate Gyrus
  6. Neuroinflammation
  7. Working Memory
  8. Attention
  9. Inhibitory Control
  10. Motor Dexterity
  11. Developmental Neurotoxicology
  12. Developmental Neurotoxicity
  13. Neuropsychology
  14. Statistics
  15. Health Data Analytics

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