Enhancements    

Christina Sobin

 
401
Health Sciences and School of Nursing Building
El Paso Texas, 79968
Homecasobin@utep.edu
Phone Logo(915) 747-8309
HomeWeb Site
Pick UTEP Faculty Profile

CENTERS AND COMMUNITIES

NETWORKS

Christina Sobin
Professor, Public Health Sciences - Interdisciplinary Health Sciences

Dr. Sobin and her research team conduct interdisciplinary and translational research to examine brain and behavior outcomes of developmental exposure to lead, and novel solutions for mitigation in lower-income neighborhoods. Their outcome research focused on cognitive concomitants and sequelae of genetic variants that influence brain mechanisms vulnerable to the effects of developmental lead exposure. Child studies provided new evidence that the hPEPT2*2 genetic variant increased blood lead burden and predicted a specific pattern of deficits in exposed children. Results from Dr. Sobin's child studies guided the development of novel animal models and in these models, Dr. Sobin duplicated the low exposure levels of child participants, quantified loss of microglia in dentate gyrus, and characterized associated behavioral effects. These studies importantly served to substantiate the significant and lasting effects of early lead exposure at lowest levels of exposure and in an attempt to finally "fix" the problem of lead exposure in American children, the laboratory transitioned to the development of a novel child-guided approach for identifying groups of children in high-risk neighborhoods with current lead exposure, identifying the lead hazard sources in the homes, educating families regarding low-cost and safe mitigation and prevention, and are conducting follow up studies to examine whether these methods lower lead contamination in the homes (in household dust) and in the children. The mitigation approach is manualized and was designed to be readily adapted by cities across the U.S.

KEYWORDS

  1. Developmental Lead Exposure
  2. Working Memory
  3. Attention
  4. Inhibitory Control
  5. Motor Dexterity
  6. Developmental Neurotoxicology
  7. Developmental Neurotoxicity
  8. Neuropsychology
  9. Statistics
  10. Health Data Analytics Translational
  11. Interdisciplinary
  12. Animal Models
  13. Dentate Gyrus
  14. Neuroinflammation

CUSTOMIZED LINKS