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Zubair Karim

 
614
Campbell Building
El Paso Texas, 79968
Homezkarim@utep.edu
Phone Logo(915) 747-8098
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Zubair A Karim
Research Assistant Professor, Pharmacy

Dr. Karim's area of interest is understanding signaling and the SNARE secretory machinery in platelets as well as to understand their contribution to health and disease. The platelets’ role is to sense vascular damage and to promote clot formation and tissue repair. Secretion from their three granular stores is essential to hemostasis and the goal of his research program is to understand the mechanisms of this secretory process. In the resting platelet, hemostatic and tissue repair-inducing components are stored in three types of membrane bound granules. Upon stimulation, these granules are targeted to specific sites on the platelet's plasma membrane where the granule membranes fuse with the plasma membrane thus releasing the granule contents. Dr. Karim's research studies are designed to determine what platelet proteins are involved in the steps leading to secretion (i.e., IKK). Also, Dr. Karim is specifically interested in how the activity of this protein is controlled by the signaling cascades that are initiated by external events such as vascular damage.

KEYWORDS

  1. Platelet biochemistry
  2. Cell biology
  3. Cell signaling
  4. Ubiquitination
  5. SNARE machinery
  6. Thrombosis and hemostasis.

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