Major Theme: Neurobiological Basis of Brain Functions and Diseases: My research examines how the brain adapts to experience and how disruptions in this process contribute to brain disorders across the lifespan. Using the genetically powerful model organism Drosophila melanogaster, I integrate molecular genetics, neural circuitry, and behavior to uncover conserved biological mechanisms underlying learning, memory, motivation, and inhibitory control – functions that are central to human cognition and mental health.A key contribution of my work has been clarifying how neuromodulatory systems, particularly dopamine and related signaling pathways, regulate behavioral flexibility and impulse control. By modeling gene–environment interactions that drive cognitive dysfunction in conditions such as substance use disorders and Alzheimer’s disease and related dementias, my research bridges fundamental discovery with translational relevance. Sustained by continuous external funding, my research program has produced high-impact publications, delivered robust training for students and early-career scientists, and catalyzed interdisciplinary collaboration, strengthening institutional prominence and national research visibility.