Exposure to compounds containing carbon-fluorine bonds may damage biomolecular structures and disrupt neurological function, but the interactions underlying these effects remain unclear. Preliminary experimental and computational findings link selected per- and polyfluoroalkyl substances to altered gene expression, impaired cellular structures, loss of dopamine-producing neurons, and movement deficits. Researchers will examine whether exposure changes activity in neuroprotective gut bacteria, affects the metabolic state of neuronal cells, and triggers protein misfolding or aggregation. Work will also assess effects on neuronal structures and movement in a preclinical model. Findings will provide a basis for mapping interactions between these persistent chemicals and amyloid-forming proteins through future experimental and computational studies.