This project investigates the synthesis of unusual glycan partial structures found on the cell surface of the parasites L. major or L. tropica: two parasites of the Leishmania genus that cause cutaneous leishmaniasis. We hypothesize that a differential diagnosis between cutaneous leishmaniasis infections caused by these two Leishmania species will be possible using patient sera, chemiluminescent ELISA, and synthetic, immunogenic glycotopes present on the cell surfaces of L. major or L. tropica, but not both.