This project seeks to tissue engineer a customized, cardiac patch to repair damaged heart tissue. Human-induced pluripotent stem cells (hiPSCs) will be transformed into specific heart tissue cell types, include cardiomyocytes (CMs), endothelial cells (ECs) and smooth muscle cells (SMCs). These different cells will then be printed in various ratios and in specific arrangements to optimize the repair patch, and the patch will be tested for functionality and in-vivo integration into native heart tissue.