Tissue engineering device and construction of vascularized dermis

Tissue engineering device and construction of vascularized dermis
Inventors: Thomas Boland
Patent No. 10,195,644

This patent application relates to cell printing technology and tissue engineering. The disclosed embodiments further relate to a vascularized dermis produced using cell printing techniques. The disclosed embodiments also relate to an intraoperative adipose tissue engineering device.

An inkjet printing method, system, and computer-usable tangible storage device to print cells and biomaterials for three-dimensional cellular scaffolds and engineered skin grafts are disclosed. The process simultaneously deposits living cells, nutrients, growth factors, therapeutic drugs along with biomaterial scaffolds at the right time and location. This technology can also be used for the microvasculature fabrication using appropriate human microvascular endothelial cells and fibrin to form the microvasculature. When printing human microvascular endothelial cells in conjunction with the fibrin, the cells aligned themselves inside the channels and proliferated to form confluent linings. The 3D tubular structure was also found in the printed patterns. Simultaneously printing biological materials to form a three-dimensional cellular scaffold promotes human microvascular endothelial cell proliferation and microvasculature formation.

Issue Date: 02/05/2019
Application Date: 02/13/2013
Post Date: 05/07/2018

UTEP Docket No: 2011-015