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Composition and methods for modulation of the octopamine receptor and its homologs

Composition and methods for modulation of the octopamine receptor and its homologs
Inventors: Kyung-An Han
Patent No. 10,306,887

Description:
"This patent application embodies a novel target to control reproduction. Ovulation is a primary step in oviposition, representing an important target to control insect pests and vectors. The inventors report that the beta adrenergic-like octopamine receptor Octβ2R serves as a key signaling molecule for ovulation and recruits protein kinase A and Ca2+/calmodulin-sensitive kinase II as downstream effectors for this activity. These observations suggest that Octβ2R has distinct signaling capacities in vivo and activate multiple signaling pathways to induce egg laying. The findings reported here narrow the knowledge gap and offer insight into novel strategies for insect control. "

Abstract:
Embodiments of the invention are directed of compositions for activation or inhibition of the Octβ2 receptor and uses thereof. The inventors have discovered that the beta adrenergic-like octopamine receptor Octβ2 serves as a key signaling molecule for ovulation and recruits protein kinase A and Ca2+/calmodulin-sensitive kinase II as downstream effectors for this activity. Octβ2R homozygous mutant females are sterile, and display normal courtship, copulation, sperm storage and post-mating rejection behavior but were unable to lay eggs.

Issue Date: 06/04/2019
Application Date: 02/03/2017
Post Date: 05/09/2018

UTEP Docket No: 2014-011